Speaker

Anne Bertolotti, Ph.D., joined the Medical Research Council Laboratory of Molecular Biology (LMB) in Cambridge in 2006 where she is continues to be a group leader as well as being joint Head of the Neurobiology Division. She completed her doctoral training at the University of Strasbourg, France, under Pierre Chambon and Laszlo Tora, working on transcription, and subsequently conducted postdoctoral research with David Ron at the Skirball Institute of Biomolecular Medicine, NYU Medical Center, discovering components of the integrated stress response.

Bertolotti's research has made seminal contributions to understanding protein quality-control mechanisms and cellular defenses against misfolded proteins that accumulate in neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and motor neuron diseases. Her laboratory has translated these discoveries into therapeutic strategies, identifying molecules that boost cellular defense mechanisms — two of which demonstrated efficacy in phase 2 and phase 2a clinical trials for ALS.

Her many honors include election as an EMBO Young Investigator (2005), an ERC Consolidator Grant (2013), EMBO Membership (2013), the Hooke Medal (2014), Fellowship of the National Academy of Medical Sciences UK (2017), Wellcome Trust Investigator and Discovery Awards (2017, 2024), the GlaxoSmithKline Award from the Biochemical Society (2018), and the IUBMB Jubilee Award Lecture (2025).

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