Biological processes happen in three dimensions and play out over varying timescales. With recent breakthroughs in structural and AI-driven approaches, it is becoming possible to see and understand how individual macromolecules and the complexes they form work in complex cellular environments. Beyond individual cells, structural biology can now encompass tissue- or organism-level questions.

This meeting will focus on the latest advances in our understanding of biological processes through the lens of emerging structural and computational technologies.

Themes will include:

• Protein complexes in nucleus and in other organelles
• Cytoplasmic and membrane proteins
• Signaling dynamics
• Structural virology and host-pathogen interactions
• Structural analyses beyond individual cells
• Further topics covered will include progress in protein design and future directions for structural analysis in situ.